【摘要】 目的 :探讨血管内皮生长因子 C (VEGF C)在早期子宫颈癌组织中的表达及与子宫颈癌侵袭、转移的关系。方法 :应用免疫组化S P法检测 6 3例子宫颈癌及 2 0例正常子宫颈组织VEGF C表达 ,以CD34检测子宫颈癌组织中微血管密度 ,分析VEGF C的表达与子宫颈癌的组织学类型、临床分期、细胞分化程度、淋巴结转移及肿瘤微血管密度的关系。结果 :VEGF C在正常子宫颈组织中不表达 ,在子宫颈癌中的阳性表达率为 6 1 .2 %。VEGF C表达与子宫颈癌盆腔淋巴结转移呈正相关 ,VEGF C阳性表达患者腹膜后淋巴结转移率 4 8.8%。阴性表达患者淋巴结转移率 1 5 .0 % (P =0 .0 1 )。VEGF C表达水平与肿瘤大小、临床分期、年龄、组织学类型及分级无关 (P >0 .0 5 )。VEGF C表达与子宫颈癌微血管密度无明显关系 (P >0 .0 5 )。结论 :VEGF C表达与肿瘤盆腔淋巴结转移有关 ,而与肿瘤微血管密度无明显关系。VEGF C表达增强预示子宫颈癌盆腔淋巴结转移更多还原

【Abstract】 Objective:To study the expression of vascular endothelial growth factor C(VEGF C) in the early stage of cervical carcinoma and its relationship with the lymphnode metastasis in cervical carcinomas.Methods:Immunohistochemistry S P method was used to detect the expression of VEGF C in 20 cases of normal cervical tissues and 63 cases of cervical cavcinoma.The microvessel density was detected with CD34 in VEGF C positve and negative groups respectively.The correlation between VEGF C and histological types,cell differentiation,clinical stages,lymph nodes metastasis and the microvessel density was analyzed stastistically.Results:VEGF C was expressed in cervical carcinomas but not in normal cervical tissues.The positive rate of VEGF C was 61.2% in cervical carcinomas.There was positive correlation between the expression of VECF C and lymph node metastasis in cervical carcinomas.The lymph node metastasis rate was 48.8% in patients with VEGF C positive and 15.0% in patients with VEGF C negative( P =0.01).The expression level of VEGF C was not related to the tumor size,histological types or cell differentiation( P >0.05).The expression of VEGF C was not related to tumor microvessel dentisty in cervical carcinomas( P >0.05).Conclusions:Expression of VEGF C in cervical carcinomas was significantly associated with lymph node metastasis in cervical carcinoma,but the expression has no relation with the tumor microvessel dentisty.The increase of VEGF C suggests lymphnode metastasis.VEGF C plays an important role in promoting pelvic lymph node metastasis in cervical carcinomas.更多还原