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参麦注射液对垂体后叶素诱发小鼠心肌缺血的保护作用

Protective effect of Shenmai injection on pituitrin-induced myocardial ischemic injury in mice

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【作者】 胡代菊马珺赵晶晶赵小康李清王蓓蓓

【Author】 HU Dai ju,MA Jun,ZHAO Jing jing,ZHAO Xiao kang,LI Qing,WANG Bei bei (Faculty of Clinical Medicine,Bengbu Medical College,Anhui 233003,China)

【机构】 蚌埠医学院医学系蚌埠医学院医学系 2000年级安徽蚌埠2330032000年级安徽蚌埠233003

【摘要】 目的 :观察参麦注射液对心肌缺血的保护作用。方法 :实验动物随机分为两组 ,参麦注射液组 :参麦注射液 0 .2ml/1 0g腹腔注射 ,每天 2次 ;缺血组 :生理盐水 0 .2ml/1 0g腹腔注射 ,每天 2次 ,3天后腹腔注射垂体后叶素 2 0u/kg诱导急性心肌缺血 ;观察心电图变化 (J点改变及心率变化 )。结果 :与缺血组比较 ,参麦注射液明显减少心肌缺血心脏的心电图J点的抬高幅度 (P <0 .0 1 ) ,并能抑制心肌缺血所致的心率减慢 (P <0 .0 1 )。结论 :参麦注射液有预防缺血性损伤、保护心脏的作用

【Abstract】 Objective:To observe the protective effect of Shenmai on the myocardial ischemic injury in mice.Methods:The experimental animals were divided into two groups randomly.In the Shenmai group,the mice were injected Shenmai intraperitoneally twice a day(0.2 ml/10 g,ip).In the ischemic group,the mice were given normal saline twice a day(0.2 ml/10 g,ip).Three days later,pituitrin(20 u/kg) was injected intraperitoneally to induce myocardial ischemic injury.The electrocardiogram was recorded.Results:Shenmai injection reduced the rise amplitude of J spot in electrocardiogram( P <0.01).The heart rate of Shenmai group did not significantly slow down( P < 0.01 ).Conclusions:These results demonstrate that Shenmai injection can protect myocardium from ischemic injury.

  • 【文献出处】 蚌埠医学院学报 ,Journal of Bengbu Medical College , 编辑部邮箱 ,2004年03期
  • 【分类号】R285
  • 【被引频次】12
  • 【下载频次】201
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