【摘要】 目的 :研究白蒺藜有效组分对心肌缺血再灌注损伤 (IRI)的影响及可能机制。方法 :测定白蒺藜有效组分对在体大鼠心肌缺血再灌注模型的心肌梗死面积、肌酸磷酸激酶 (CK MB)活性水平、血清一氧化氮 (NO)和血浆内皮素 (ET 1 )的影响 ,并观察其超微结构的变化。结果 :与假手术组相比 ,模型组血清NO降低 ,血浆ET 1增高 ,同时其超微结构明显异常 ;而白蒺藜有效组分治疗组可将上述损害减轻并缩小梗死面积。结论 :白蒺藜有效组分可通过改善内皮细胞功能 ,明显减轻心肌IRI。更多还原

【Abstract】 Objective:To study the influence of effective constituents of tribulus terrestris L on myocardial ischemic reperfusion injury(IRI).Methods:The extension of the myocardial areas,CK MB activity and NO content in the serum,the content of ET 1 in the plasma,and the ultrastructure changes in myocardium were observed.Results:As compared with the sham operated group,there were abnormal changes of myocardial ultrastructure in the model group,the level of NO in serum decreased,and the content of ET 1 in plasma increased after IRI.Effective constituents of tribulus terrestris L reversed the indices mentioned above markedly.Conclusions:This study shows that effective constituents of tribulus terrestris L may be regarded as an agent with a marked cardioprotective action against ischemia reperfusion induced myocardial injury by protecting the coronary endothelium in vivo model of the rat heart.更多还原