【摘要】 目的 :探讨抗DNP抗体、抗Sm抗体、抗ds DNA抗体联合检测在系统性红斑狼疮 (SLE)诊断中的价值。方法 :用免疫印迹法检测抗Sm抗体 ,免疫斑点法检测抗ds DNA抗体 ,胶乳免疫法检测抗DNP抗体。结果 :5 7例SLE患者 ,抗DNP抗体阳性率为 73.7% ,抗Sm抗体阳性率 33.3% ,抗ds DNA抗体阳性率 6 1 .4 % ,三者联合检测阳性率达 94 .7%。结论 :抗DNP抗体、抗Sm抗体、抗ds DNA抗体联合检测可提高对SLE诊断的阳性率 ;对SLE病情的追踪和预后判定有重要作用 ;用抗DNP抗体检测代替LEC检测可直接检测血清中的狼疮因子 ,弥补了因实验条件所致LEC检测阳性率低等缺陷更多还原

【Abstract】 Objective:To investigate the significance of anti DNP antibody,anti Smith antibody and anti double stain DNA antibody in the patient with systemic lupus erythematosus(SLE).Methods:Anti Smith antibody was detected by immuno blotting technique,anti double stain DNA antibody by dot immunofiltration assay,and anti DNP antibody by latex immunoassay.Results:Among the 57 cases,the positive rates of anti DNP antibody,anti Smith antibody, and anti double stain DNA antibody were 73.7%,33.3% and 61.4%,respectively.The total positive rate was 94.7%.Conclusions:In diagnosing SLE,allied examination of anti DNP antibody,anti Smith antibody,anti double stain DNA antibody can upraise the positive rate.The above tests are important in tracing patient’s condition and judging the prognosis of SLE.Detecting serum anti DNP can directly improve the detection rate of SLE instead of LE cell(LEC) detection.更多还原