【摘要】 目的 :研究多种肿瘤标志物蛋白芯片诊断系统 (C1 2 ) 1 2种肿瘤标志物的联合检测在原发性肝癌诊断中的价值。方法 :用C1 2定量检测 1 2 8例原发性肝癌患者、2 3例肝硬化患者和 98名正常人血清的 1 2种常见的肿瘤标志物 ,包括糖链抗原 1 2 5(CA1 2 5 )、血清铁蛋白 (Ferritin)、癌胚抗原 (CEA)、甲胎蛋白 (AFP)、糖链抗原 1 9 9(CA1 9 9)、糖链抗原 1 5 3(CA1 5 3)、神经元特异性烯醇化酶 (NSE)、糖链抗原 2 4 2 (CA2 4 2 )、前列腺特异性抗原 (PSA)、游离前列腺特异性抗原 (Free PSA)、人类生长激素(HGH)、人绒毛膜促性腺激素 (β hCG)。 结果 :通过多指标联合检测 ,1 2 8例原发性肝癌患者血清肿瘤标志物中有 1 1 2例肿瘤标志物阳性 ,灵敏度从AFP单指标测定的 5 8.6 %提高到 87.5 % ,特异性达 83.5 % ;ferritin阳性率达 4 1 .4 % ,原发性肝癌患者血清中 β hCG、NSE、PSA、HGH、CA1 9 9、CA1 2 5、CEA、AFP、CA1 5 3、CA2 4 2与正常对照组和肝硬化组比较差异均有显著性 (P<0 .0 1 )。结论 :联合检测与传统的单指标检测相比灵敏度大大提高更多还原

【Abstract】 Objective:To study the value of 12 tumor markers in protein chip system for multi tumor detection(C12) in the diagnosis of the primary liver cancer.Methods:The system of C12 was used to quantitatively detect the 12 tumor markers(CA125,Ferritin,CEA,AFP,CA19 9,CA15 3,NSE,CA242,PSA,Free PSA,HGH,β hCG) in the sera of 128 patients with primary liver cancer,23 patients with hepatocirrhosis,and 98 healthy controls.Results:The quantitative detection proved positive in 112 of the 128 patients with primary liver cancer;the sensitivity was raised from 58.6% by AFP single index detection to 87.5% and the specificity reached 83.5 %.In addition,Ferritin positive rate achieved 41.4%,and in the sera of some liver cancer patients,the difference of β hCG,NSE,PSA,HGH,CA19 9,CA125,CEA,AFP,CA15 3 and CA242 items was statistically significant,compared with the contrast group and hepatocirrhosis group( P <0.01).Conclusions:The allied detection is more effective than the traditional single index detection.更多还原