【摘要】 目的 :研究大剂量生脉注射液对慢性心功能衰竭 (简称心衰 )患者凝血功能的影响。方法 :将 6 0例慢性心衰患者随机分为治疗组 (即生脉注射液组 )和对照组 ,每组各 30例 ,治疗组给予生脉注射液加西药常规治疗 ,对照组仅西药常规治疗 ,观察用药前后心功能改善程度及血浆P 选择素、血管性血友病因子(vWF)和D 二聚体水平的变化。结果 :治疗组临床显效率与总有效率明显高于对照组。心衰患者血浆P 选择素、vWF和D 二聚体水平明显高于健康人 ,治疗后两组患者血浆P 选择素、vWF和D 二聚体水平均下降 ,治疗组优于对照组。结论 :慢性心衰患者 ,体内存在着高凝状态 ,大剂量生脉注射液可改善慢性心衰患者的凝血功能 ,可能在一定程度上减少心衰患者血栓事件的发生和发展。更多还原

【Abstract】 Objective:To investigate the effect of Shengmai Injection (SMI) on blood coagulation in patients with chronic heart failure (CHF). Methods:Sixty patients with CHF were randomly divided into two groups, the 30 patients in the treated group were treated with SMI plus conventional treatment of western medicine, and the 30 in the control group treated with conventional treatment alone. The changes of cardiac function were observed and levels of plasma P-selectin, von Willebrand′s factor (vWF) and D-dimer were determined. Results:The total effective rate and the markedly effective rate in the treated group were higher than those in the control group respectively. The levels of P-selectin, vWF and D-dimer lowered in both groups significantly after treatment, but the effect of lowering was better in the treated group than that in the control group. Conclusion:Hypercoagulative state exist in patients with chronic heart failure. SMI could improve the state in patients, which may reduce the occurrence and developing of emboic events to certain extent.更多还原