【摘要】 为观察三黄软膏药物外用的安全性 ,进行了动物完整皮肤及破损皮肤长期接触三黄软膏 ,经皮肤渗透对局部及全身产生的毒性和反应的恢复程度 ,用三黄软膏 2g·kg-1、10g·kg-1剂量 (分别相当于 6 0kg人临床用量的 10、5 0倍 )连续对家用兔外用给药4周及停药恢复性观察 2周。结果表明给药期动物的皮肤状况、全身症状、行为活动、摄食、粪便性状、体重增长、血液学均未见明显的毒性反应 ,而高剂量组动物血液生化指标AST、ALT明显增高 ,病理组织学检查时肝水肿明显 ,可见有一定的毒性反应 ;停药期动物的血液生化指标AST、ALT肝组织病理组织学检查恢复正常 ,其他各项指标均未见明显的毒性反应 ,可见该毒性反应是可逆恢复的。表明三黄软膏在临床用药范围内连续使用是比较安全的。更多还原

【Abstract】 In order to observe the safety of externally-applied SANHUANG ointment (SHO), SHO was externally applied on rabbit intact and injured skin with doses of 2g﹒kg-1 and 10 g﹒kg-1 (equal to 10 and 50 times of the clinical dose for an adult of 60 kg ) for four weeks and then withdrawn; and the next two weeks were used for observing the toxicity of SHO and the recovery of the local and general toxic reactions caused by SHO externally applied. The results showed that during the application of SHO, no obvious toxic reactions were found in the skin conditions, general symptoms, behavior activity, ingestion, stool property, body weight increase and hematology; while the hematological biochemical indices AST and ALT of the high-dose group ascended remarkably, and the histopathological examinations showed significant edema of the liver, which meant somewhat toxic reactions. During the withdrawal, the hematological biochemical indices AST and ALT recovered to normal, and no obvious toxic reactions were found in all other indices, suggesting that the toxic reactions are reversible and reducible and the continuous application of SHO has relative safety in the clinical application.更多还原