【摘要】 目的 :观察异舒吉 (isoket)与依那普利联合治疗不稳定型心绞痛 (UAP)的临床疗效。方法 :将 60例不稳定型心绞痛病人随机分为两组 ,治疗组 3 0例给异舒吉 ,每天 3 0mg ,依那普利每次 5mg～ 10mg口服 ,每日 2次 ;对照组 3 0例单用异舒吉。两组基础治疗相同 ,14d为一疗程。观察治疗后心绞痛的发作频率、程度、维持时间、心率、血压和心电图变化。结果 :异舒吉联合依那普利治疗UAP临床总有效率为93 .3 % ,心电图改善总有效率为76.6% ,与对照组比较有统计学意义 (P <0 .0 5 )。结论 :依那普利能加强异舒吉的抗心绞痛及抗心肌缺血作用 ,延缓或防止耐药性产生 ,降低UAP的病死率及AMI发生率。更多还原

【Abstract】 Objective:To observe the clinical therapeutic effect of enalapril accompanied with isoket for treatment of unstable angina pectoris(UAP).Methods:Sixty patients with UAP were randomly into control group(n=30)and therapy group (n=30).The control group received isoket(30 mg.5%glucose injection 250mol qdivd)and the therapy group were used with isoket phus enalapril(5mg～10mg bid.po).The basis treatment of both groups was the same.The course of treatment was 14 days.The frequency of attack,degress and duration of the angina pectoris after treating,the heart rate,flood pressure and the change of ECG of the patients were observed.Results:After treatment for 14 days,the clinical tatal effective rate was 93.3%,and the total effective rate of improvement of ECG was 76.6% in the therapy group.The difference of therapy group compared with contrast group was notable(P<0.05).Conclusion:The enalapril can intensify the effect of isoket for resisting angina pectoris and myocardial ischemia,can delay or prevent happening of the drug resistance and reduce the mortality of UAP and the incidence of AMI.更多还原