【摘要】 我们研究了合肥地区汉人中血管紧张素原基因 2 35位密码子突变相关的基因型多态性 ,白介 - 1、白介 - 6、肿瘤坏死因子等细胞因子的血浓度及多种生活因素在原发性高血压组及其同胞健康对照组中的不同。发现中重度高血压AGT2 3 5的TT型增多 ,也发现多种生活因素、某些细胞因子血浓度升高及AGT2 3 5的TT型增多与高血压的发生并行存在关系密切。因此 ,高血压的发病可能和环境、遗传、免疫等多种病因同时存在的相加作用有密切关系。更多还原

【Abstract】 We observed the differences among the Han people in the area of Hefei in effects of genotype polymorphism associated with the mutation in coden of AGT235 (the mutation in coden of angiotensinogen gene235) and the concentrations of interleukin-1,interleukin-6 as well as tumor necrosis factors in blood on both patients with primary hypertension and the health control group of the same race. The finding is TT-type of AGT235 is increased in both moderate and severe groups with hypertension. And various life style factors, the increased concentrations of certain cytokines in blood and increased TT-type of AGT235 are closely related to the risk of hypertension. We conclude that the joint effects of various causes such as environment,heredity and immunity are responsible for the onset of hypertension.更多还原