【摘要】 目的　观察产前采用地塞米松治疗妊娠肝内胆汁瘀积症 (ICP)的效果。方法　对 133例ICP孕妇按产前地塞米松使用情况分为观察组及对照组 ,回顾分析地塞米松治疗前后肝功能指标和妊娠结局的改变。结果　观察组妊娠瘙痒有所缓解 ,血清转氨酶、胆汁酸和胆红素水平下降 ,重要的是产时胎儿窘迫和新生儿窒息的发生率降低 ,孕周延长 ,而产后出血、产褥感染无明显增加。结论　产前采用地塞米松治疗ICP安全、有效的药物。更多还原

【Abstract】 Objection: Observing therapy effect of dexamethasone to intrahepatic cholestasis of pregnancy(ICP) antepartum. Methods: 133 pou graveda of ICP was divided to observe group and contrast group according to method of usng dexamethasone differently antepartum, lood back and analysis alteration of liver function marker and cyesis end to use dexamethasone for ICP pretreatment and post?treatment. Results: Pruritus of pregnancy can be remission, blood serum transaminase and bile acid and bilirubin level descent,loss incidence of fetal distress and apnea in the newborn is important, gestation period elongation, incidence increase of postpartum hemorrhage and puerperal infection is not obviously. Conclusion: Using dexamethasone for ICP is safety and utility antepartum.更多还原