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痛可停胶囊挥发油β-环糊精包合物的实验研究
Studies on β-Cyclodextrin-Inclusion Complexes of Volatile Oil from the Tongketing Capsules
【摘要】 目的 研究β-环糊精包合痛可停胶囊挥发油的最佳工艺。方法 采用不等水平正交试验法,以包合物油利用率为指标优选包合工艺。结果 最佳工艺条件为:挥发油加40倍量水,4倍量β-环糊精,以胶体磨研磨10 min包合,包合物70℃烘干。结论优选得到的工艺简单、可行,适合痛可停胶囊的大生产。
【Abstract】 Objective To study the optimum inclusion process for volatile oil from Tongketing capsules. Methods The study was carried out with orthogonal test at different levels. The utilization ratio of volatile oil was used as the index to optimize the inclusion process. Results The optimum preparation conditions for inclusion were: oil: β-cyclodextrin: water was 1: 4: 40 (V: V: V). The inclusion time was 10rain and inclusion complexes was dried at 70℃. Conclusion This optimized process is simple, efficient and can be used for the production of Tongketing Capsule on a large scale.
【Key words】 @ Tongketing Capsule; Oils, volatile; Cyclodextrins; Orthogonal test; Pharmaceutical technology (TCD);
- 【文献出处】 中药新药与临床药理 ,Traditional Chinese Drug Research & Clinical Pharmacology , 编辑部邮箱 ,2003年06期
- 【分类号】TQ461
- 【被引频次】1
- 【下载频次】64