【摘要】 目的 分析胰高血糖素瘤综合征(GS)的临床特点、诊断和治疗,以提高临床医师对本病的认识和诊治水平。方法 回顾性分析4例已确诊胰高血糖素瘤综合征的临床表现、实验室检查和诊治经过。结果 4例患者均具有典型的坏死松解性游走性红斑(NME)、血胰高血糖素明显升高和肝脏转移灶。经手术、生长抑素等治疗后,皮损有不同程度消退,血胰高血糖素水平也有所下降。结论 坏死松解性游走性红斑是胰高血糖素瘤综合征最特征性的临床表现,但确诊尚需结合皮损的组织病理检查、血胰高血糖素水平和各种影像学检查。手术、化疗和生长抑素是本病主要的治疗方法。更多还原

【Abstract】 Objective To study the clinical features, diagnosis, and treatment of glucagonoma syndrome (GS) for providing clues for the recognition of this disorder in clinical practice. Method The clinical and laboratory findings of four confirmed patients with GS were analyzed retrospectively. Results All four patients had typical clinical manifestations of necrolytic migratory erythema (NME), elevated glucagon level in serum and hepatic metastasis. The skin rashs disappeared gradually and serum glucagon level decreased after operation and somatostatin treatment. Conclusions NME is the most specific clinical finding of GS. Biopsy of the lesions, glucagon level in serum and various radiological examinations should be done in order to confirm the diagnosis. Surgical resection, chemotherapy, and somatostatin are the main therapies of GS.更多还原