【摘要】 目的 研究炎症性肠病患者抗中性粒细胞胞浆抗体(ANCA)的阳性率、特异性及与炎症程度病变范围的相关性,探讨ANCA作为溃汤性结肠炎患者辅助诊断指标的价值。方法 应用间接免疫荧光法检测42例溃疡性结肠炎患者、32例非溃疡性结肠炎引起的腹泻患者及35例正常对照者血清ANCA阳性率。结果 溃疡性结肠炎组pANCA阳性率为69.1％。非溃疡性结肠炎组总的pANCA阳性率为3.5％,P<0.05。pANCA对溃疡性结肠炎诊断的特异性为93.8％。核周型抗中性粒细胞胞浆抗体(pANCA)阳性率与病变范围无关(P>0.05)。结论 ANCA对炎症性肠病特别是溃疡性结肠炎的辅助诊断具有意义,同时具有较高的鉴别诊断价值。更多还原

【Abstract】 Objective To analyze the positive rate and specificity of antineutrophil cytoplasmic antibody (ANCA) in inflammatory bowel patients and the relationship between ANCA and the disease, and to understand the significance of ANCA on the diagnosis of inflammatory bowel disease. Methods Indirect immunofluorescence was used in detecting the positive rate of ANCA in the serum of 42 ulcerative colitis patients, 32 non - ulcerative colitis patients and 35 normal people. Results The positive rate was 69.1% and 3.5% in ulcerative colitis patients and non - ulcerative colitis patients respectively, and there was a significant difference between them ( p < 0.05). The specificity of ANCA in diagnosis of inflammatory bowel disease was 93.8% . There was no signicant relationship between ANCA and the extent of disease (p > 0.05) . Conclusions ANCA is effective and specific in diagnosing inflammatory bowel disease, especially ulcerative colitis.更多还原