【摘要】 目的:探讨聚乙二醇重组人粒细胞集落刺激因子(PEG-rhG-CSF,商品名津优力)对心血管功能的药理作用。方法:采用麻醉犬心电图、心输出量、冠脉血流量、左室做功和心肌耗氧量等指标,观测津优力对心脏血流动力学及心肌耗氧量的影响。结果:津优力对于麻醉犬心脏血流动力学和心肌耗氧量的各项指标和空白组相比均无明显差异。结论:津优力对麻醉犬的心血管功能没有明显的直接、即刻作用。更多还原

【Abstract】 Objective: To investigate the pharmacological effects of PEG-rhG-CSF on heart functions in dogs. Methods:The parameters including ECG, heart output, coronary blood flow,left ventricular function and myocardial oxygen consumption in normal anaesthetic dogs were adopted in the study. Results:The parameters of PEG-rhG-CSF-injected dogs have evident difference with that of normai dogs.Conclusion:PEG-rhG-CSF has no obvious direct effect on the cardiac functions of anaesthetic dogs.更多还原