【摘要】 博莱霉素是一族具有独特结构和作用的广谱抗菌抗肿瘤抗生素 ,由 5个氨基酸、2个六碳糖和 1个氨基侧链构成 ,各组分分子结构间差异仅在于氨基取代侧链的不同。博莱霉素对头颈部鳞癌、恶性淋巴瘤有效 ,且不引起白细胞减少 ,不抑制机体免疫功能 ,也不损害造血系统。博莱霉素杀伤肿瘤细胞的机制是在体内与铁、氧结合生成复合物 ,与染色体作用后进攻DNA靶点 ,引发DNA降解反应 ,从而抑制肿瘤细胞DNA合成。笔者综述了博莱霉素族抗生素的研究进展和应用前景。更多还原

【Abstract】 Bleomycin(BLM)is a family of broad-spectrum antibiotics with special structures and functions.BLM consists of 5 molecule of amino acids,2 molecule of hexoses,and 1 molecule of amino-side chain.Structure of the family members is only different in substituted side chain.BLM is effective in treatment of squama cancer of head and cervix,and malignant lymphoma without decreasing leucocytes,inhibiting immuno-functions,and damaging hemopoietic system.The anti-cancer mechanism of BLM is the inhibition of DNA synthesis by compound BLM formed from oxygen and iron.In this paper,the progress of BLM research is reviewed.更多还原