【摘要】 目的 :评价 5 羟色胺再摄取抑制剂氟西汀治疗高血压伴抑郁障碍的疗效及安全性。方法 :采用随机单盲模拟对照试验 ,共 6 8例高血压伴抑郁障碍患者随机分为氟西汀组与多塞平组各 34例 ,在常规抗高血压药物治疗基础上 ,氟西汀组用氟西汀 2 0mg·d-1,多塞平组用多塞平 75mg·d-1,随访 12周 ,以高血压症状计分及Zung积分减少 5 0 %或以上为治疗有效 ,用Zung抑郁自评量表评定疗效 ,治疗时出现的症状量表 (TESS)评定安全性。 结果 :氟西汀组有效率 79.4 1% ,多塞平组 73.5 3% ,2组疗效差异无显著性 (P >0 .0 5 )。起效时间氟西汀组 3～ 4周 ,多塞平组 6～ 8周 ,2组比较差异有显著性 (P <0 .0 5 )。不良反应发生率氟西汀组 38.2 % ,多塞平组 70 .6 % ,2组比较差异有显著性 (P <0 .0 5 )。结论 :氟西汀治疗高血压伴抑郁障碍有效且较安全。更多还原

【Abstract】 Objective:To evaluate the efficacy and safety of fluoxetine in treatment of depression associated with hypertension.Methods:68 patients with depression associated with hypertension were randomly divided to receive fluoxetine(20mg·d -1,n=34) or doxepin (75mg·d -1,n=34)and followed-up for 12 weeks.The efficacy was assessed by Zung Depression Scale and safety was assessed by Treatment Emergent Symptom Scale.Results:The total effective rates in fluoxetine and doxepin arm were 79.41% and 73.53% respectively without significant difference between the two groups(P> 0.05).The onset of action was 3～4 weeks for fluoxetine arm and 6～8 weeks for doxepin arm and there was significant difference between them(P< 0.05).The incidence rate of ADRs were 38.2% for fluoxetine arm and 70.6% for doxepin arm with significant difference between them(P<0.05).Conclusion:Fluoxetine is an effective and safe agent for treatment of depression associated with hypertension.更多还原