【摘要】 目的 :探讨活血化瘀中药当归对淋巴微循环的影响。方法 :16只血瘀症大鼠被随机分成实验组和对照组 ,每组 8只。实验组给予当归注射液 (2 0 m g/ kg)进行第 1次治疗 ,2 0 min后给予输血 +当归 (2 0 mg/ kg)进行第 2次治疗 ;对照组给予生理盐水代替当归注射液治疗。通过微循环显微电视录像技术连续观察记录肠系膜淋巴微循环的变化。结果 :实验组大鼠经当归注射液第 1次治疗后 ,微淋巴管收缩幅度明显增加 ,自主收缩频率增强 ,收缩分数 (Index )、总收缩活性指数 (Index )及淋巴管动力学指数 (L.D Index)显著高于对照组(P均 <0 .0 5 )。第 2次治疗后 ,可见微淋巴管口径扩张 ,自主收缩频率、Index 、L .D Index均显著高于对照组(P均 <0 .0 1) ,而 Index 与对照组比较无明显差异 (P>0 .0 5 )。结论 :当归注射液能明显增强血瘀证大鼠肠系膜淋巴管自主收缩频率及收缩性 ,补充血容量后微淋巴管口径明显扩张 ,淋巴液回流增加。更多还原

【Abstract】 Objective: To study the effect of Chinese angelica(当归) on lymph microcirculation. Methods: Sixteen blood stasis rats were divided randomly into treatment and control groups (n=8 in each group). The treatment group was firstly treated with Chinese angelica parenteral solution (当归注射液,20 mg/kg), after 20 minutes, refusion of withdrawn blood and Chinese angelica parenteral solution was performed secondly. Chinese angelica parenteral solution was replaced by normal saline in control group. Changes of mesenteric lymph microcirculation were observed and recorded by using a video microscope with TV recorder. Results: After the treatment of Chinese angelica, the contracting extent and spontaneous contraction frequency were increased, contracting fraction(IndexⅠ), contracting activity(IndexⅡ)and lymphatic dynamics(L.DIndex) of microlymphatics were significantly higher than those of control group (all P<0.05). After the second treatment, the all mentioned indexes except Index Ⅰ were significantly higher than those of control group (all P<0.01). Conclusion: Chinese angelica parenteral solution can increase the contractility and spontaneous contraction frequency of mesenteric microlymphatics, improve lymph backflow in blood stasis rats.更多还原