【摘要】 目的 :研究内皮素在充血性心力衰竭 (CHF)兔中的变化及加味真武汤对 CHF少阴病阳虚水停证兔内皮素的影响。方法 :采用先以寒药灌服 ,再结扎冠状动脉 ,缩窄升主动脉口径造成 CHF少阴病阳虚水停证兔模型 ,分别灌服加味真武汤、卡托普利及两者联合用药 ,并建立空白对照组 ,采血检测血浆内皮素水平。结果 :制模后兔血浆内皮素水平升高 ,与制模前比较有显著性差异 (P<0 .0 5 ) ;用药后血浆内皮素水平下降 ,与空白对照组比较差异显著 (P<0 .0 1) ,但内皮素各治疗组间比较无显著差异 (P>0 .0 5 )。结论 :加味真武汤治疗 CHF的作用机制之一是其降低血浆内皮素水平。更多还原

【Abstract】 Objective: To study the effect of Jiawei Zhenwu decoction(加味真武汤) on plasma endothelium in rabbits with congestive heart failure (CHF) belonged to Yangdeficiency and waterstagnation symptom(阳虚水停证) of Saoyin disease(少阴病). Methods: By first infusing large dose of cold nature drugs, followed by ligaturing the anterior descending branch of coronary artery and gradually narrowing down their aortic caliber , the rabbit model of Yangdeficiency and waterstagnation symptom of Saoyin disease in CHF was successfully established. The rabbits were divided into four groups: traditional Chinese medicine group was infused Jiawei Zhenwu decoction, western medicine group was treated with captopril, traditional Chinese medicine and western medicine group was treated with Jiawei Zhenwu decoction and captopril, control group was not received medicine. The plasma endothelin was measured in each group. Results: The level of plasma endothelin in the model rabbit was significantly higher than that in normal rabbits( P <0.05). Jiawei Zhenwu decoction could lower the level of plasma endothelin in the model rabbit, there was obviously difference between traditional Chinese medicine group and control group ( P <0.01). There was not obviously difference between traditional Chinese medicine group and western medicine group( P >0.05). Conclusion: The low of plasma endothelin level was one of the mechanisms of treatment function of Jiawei Zhenwu decoction on CHF.更多还原