【摘要】 目的 :探讨急性脑出血 (ACH)下丘脑垂体肾上腺 (HPA)轴激素与出血量大小及中风证型间的关系 ,以阐明其发病机制。方法 :采用放射免疫分析法 (RIA)和免疫放射分析法 (IMRA)分别对 10 9例 ACH患者进行促肾上腺皮质激素释放激素 (CRH)、促肾上腺皮质激素 (ACTH)、皮质醇 (CS)血浆含量进行测定 ,分析其与出血量大小及中风中脏腑或中经络变化的关系 ,并与 30位年龄相仿健康人作对照。结果 :ACH者 HPA轴激素含量显著高于正常对照组 (P均 <0 .0 1) ,中脏腑者显著高于中经络者 (P均 <0 .0 1) ;且与出血量大小密切相关。结论 :HPA轴中的 CRH、ACTH和 CS参与了 ACH病理发生发展过程 ,其动态变化可作为判断中脏腑、中经络患者微观辨证、病情程度、预后及疗效评定的客观指标。更多还原

【Abstract】 Objective:To study the relationship between serum levels of hypothalamuspituitaryadrenal axis(HPA) hormones,bleeding quantity and apoplectic kind of tranditional Chinese medicine in the patients of acute cerebral hemorrhage(ACH).Methods:Serum corticotropinreleasing hormone(CRH),adrenocorticotropic hormone(ACTH),corticosteroid(CS) levels were determined using RIA,IMRA in 109 patients with ACH during acute stage.The changes of parameters in apoplexy involving the zangfu organs(中脏腑) and involving the channels and collaterals(中经络) were analyzed and compared with those of 30 healthy subjects for control.Results:The serum levels of HPA hormones in the patients with ACH were significantly higher than those of healthy control group(all P <0 01),and involving the zangfu organs were singnificantly higher than those of involving the channels and collaterals(all P <0 01);Levels of HPA hormones had significant relation with bleeding quantity.Conclusion:These results suggest that HPA hormones seem to take part in the development and progress in process of ACH,measurement of their contents be help to judge the fine differential diagnosis,severity of illness,predict the prognosis and evaluate the therapeutic effective in disease’s kind of apoplexy.更多还原