【摘要】 目的 :观察抗纤软肝颗粒对实验性肝纤维化时肝组织 型胶原 ( - C)、层粘蛋白 (L N)以及肝窦毛细血管化的影响。方法 :大鼠皮下注射 2 5 0 m l/ L CCl4 制备肝纤维化模型 ,并同时给于秋水仙碱、抗纤软肝颗粒小和大剂量治疗 ,用光镜和电镜观察肝组织病理变化 ,免疫组织化学法检测肝组织 - C、L N。结果 :抗纤软肝颗粒能有效抑制 - C、L N的生成和沉积 (P <0 .0 1) ,改善肝纤维化大鼠肝组织病理变化 (P <0 .0 1) ,减轻肝窦毛细血管化程度。结论 :抗纤软肝颗粒能抑制肝窦毛细血管化的形成 ,产生抗肝纤维化的作用。更多还原

【Abstract】 Objective:To observe the effect of Kangxian Ruangan granule（KRG） on hepatic sinusoid capillatization and LN,collagen Ⅳ in the livers of experimental rats with hepatic fibrosis. Methods:Rat models of the experimental liver fibrosis were induced by CCl₄. Colchicine and different dosages of KRG were given during the process of making model. Histopathological changes were examined by optical and electron microscopies. Collagen Ⅳ and LN in the hepatic tissues were detected by immunohistochemical techniques.Results:KRG inhibited collagen Ⅳ and LN accumulation in the fibrotic livers（ P <0.01）,improved the histopathological changes in the hepatic tissues in the experimental rat with liver fibrosis（ P <0.01）and attenuated the degree of the hepatic sinusoid capillatization. Conclusion:KRG could inhibit the formation of hepatic sinusoid capillatization. It had good anti-hepatic fibrosis function.更多还原