【摘要】 目的 :评价丽珠肠乐治疗慢传输性便秘的疗效。方法 :采用随机对照试验方法 ,选择慢传输性便秘 76例 ,随机分为治疗组 (39例 )和对照组 (37例 ) ,分别接受丽珠肠乐和乳果糖治疗 ,疗程 4周。观察排便次数、第 1次排便时间和排便困难变化及结肠转运时间 ,疗效评估采用模拟视觉梯度的评分方法 (10 0 m m VAS)。结果 :多数患者服药 1d即出现排便 ,治疗组和对照组分别为 6 5 .7%和 6 7.2 %。每周排便次数分别从治疗前的 (2 .1± 0 .1)次和 (2 .3± 0 .1)次增加至治疗 4周后的 (7.4± 0 .4 )次和 (7.3± 0 .5 )次 (P<0 .0 5 ) ,两组间差异无显著性意义 (P>0 .0 5 )。治疗 4周后 ,两组排便困难改善 ,分别从治疗前的 86 .5 %和 89.6 %下降至治疗后的 32 .4 %和 35 .1% (P <0 .0 5 )。治疗组 10 0 mm VAS评分为 72 .3,显著高于对照组的 5 4 .2 (P <0 .0 5 )。结肠转运时间治疗组和对照组分别从治疗前的 (82 .1± 3.5 ) h和 (79.6± 2 .9) h缩短至 (5 6 .3± 4 .2 ) h和 (5 2 .4± 2 .8) h(P <0 .0 5 )。结论 :丽珠肠乐治疗慢传输性便秘安全有效。更多还原

【Abstract】 objective: To evaluate the efficacy of Lizhu Changle(LC) in the treatment of slow transit constipation. Methods:76 patients with slow transit constipation were enrolled in this randomized controlled trial. Patients were divided into two groups treated with LC as treatment group( n =39) and lactulose as control ( n =37) for 4 weeks. The bowel frequency,date of occurrence of first motion,straining on defecation,colonic transit time (CTT) were recorded and treatment efficacy (visual analogue scale (VAS) (0-100 mm) was assessed. Results: Most patients (treatment group 65.7% vs controlled group 67.2%,respectively) had their first stool within 1 day of starting treatment. Weekly stool frequency significantly increased from (2.1±0.1)to (7.4±0.4) in the treatment group and from (2.3±0.1) to (7.3±0.5) in the control group ( P <0.05) during the treatment,which showed no significant difference between the two groups( P >0.05). At the end of the treatment,the percentage of patients with straining on defecation significantly decreased in the treatment group and the control group (32.4% vs 35.1%) compared with baseline in both groups(86.5% vs 89.6%,respectively,P <0.05) .The VAS score was significantly higher in the treatment group (72.3) than that in control group (54.2,P <0.05).Both medicine significantly decreased the CTT (56.3±4.2) h vs (52.4±2.8)h,respectively compared with baseline in the both groups (82.1±3.5)h vs (79.6±2.9)h,respectively,P <0.05). Conclusion:Single administration of LC was an effective and safe treatment for slow transit constipation.更多还原