【摘要】 目的 :通过检测大肠湿热证模型大鼠血清白细胞介素 - 1(IL- 1)、白细胞介素 - 2 (IL- 2 )、白细胞介素 - 6(IL- 6 )含量的变化 ,探讨大肠湿热证的客观指标。方法 :采用综合因素造模 (饮食加气候环境加致病生物因子 )复制成大肠湿热证动物模型 ,应用放射免疫法检测模型大鼠血清白细胞介素含量 ,给予清热祛湿方药急泻康治疗 ,观察动物模型给药后的变化。结果 :该模型无论从发病条件、病变脏腑 ,还是主要症状、体征均近似于中医大肠湿热证型 ,模型大鼠血清 IL- 1、IL- 2、IL- 6含量升高 ,经急泻康治疗后 ,症状、体征及检测指标均有改善。结论 :血清 IL- 1、IL- 2、IL- 6含量升高可能为大肠湿热证的客观指标。更多还原

【Abstract】 Objective: To explore the objective parameter of large intestine damp-heat syndrome through checking out the contents of IL-1, IL-2, IL-6 in rats with experimental large intestine damp-heat syndrome model.Methods: The animal model of large intestine damp-heat syndrome was developed by multiple factors (diet, climate and pathogenic biological factors). Blood IL-1, IL-2, IL-6 contents in the model rats were detected by radioimmunoassay. Jixiekang capsule was given to the model rats and the changes after the treatment was observed. Results: The presentation of the model was similar to large intestine damp-heat syndrome of TCM not only in pathogenic condition, but also in main symptoms and signs. IL-1, IL-2, IL-6 contents obviously increased in the rats of large intestine damp-heat syndrome. The symptoms, signs and parameters were ameliorated after the treatment by Jixiekang capsule. Conclusion: The increased IL-1, IL-2, IL-6 contents might be the impersonal parameters of large intestine damp-heat syndrome.更多还原