【摘要】 目的:观察不同剂量莪术治疗重度慢性肝损伤时的肝毒作用。方法:采用牛血清白蛋白（BSA）制造大鼠免疫性重度慢性肝损伤模型,观察肝功能、脂质过氧化反应及肝细胞膜ATP酶的变化。结果:大剂量莪术组大鼠的血清ALT升高,Alb降低（P值均小于0.05）,肝细胞膜Ca²⁺-ATPase降低（P值小于0.01）。结论:大剂量莪术可加重慢性肝损伤,临床治疗慢性肝病应禁用。更多还原

【Abstract】 Objective: To observe the side-effects of Curcuma Zedoaria with different dosage in the treatment on serious immunity chronic liver injury. Methods: Serious immuno-injured model of rats was induced by bovine serum albumin. Results: The large dosage of Curcuma Zedoaria can go up ALT and cut down Alb (P<0.05) in the rats’ blood serum, and obviously destroy the activity of Ca2 + -ATPase in hepatocyte membrane (P<0.01). Conclusion: The large dosage of Curcuma Zedoaria can obviously aggravate serious immunity chronic liver injury.更多还原