【摘要】 目的　评价拉米夫定治疗慢性乙型肝炎生存质量的改善状况。方法　分别于拉米夫定治疗前、治疗半年、1年采用SF 3 6量表测定 2 44例病人的生存质量评分。结果　与治疗前相比 ,拉米夫定治疗半年及 1年后在躯体角色RP( 9.6)、社会功能SF( 8.2 )、情绪角色RE( 11.8)和活力VT( 6.2 ) 4个领域得分有显著提高 (P <0 .0 5 ) ,主要集中在心理状态评分MCS( 3 .6)。结论　拉米夫定治疗慢性乙型肝炎病人能有效改善病人生存质量。更多还原

【Abstract】 Objective To evaluate the quality of life (QOL) improvement in patients infected with chronic hepatitis B (CHB) following treatment with lamivudine (Suzhou manufactured/100mg for 52 weeks). Methods 244 patients randomly selected from lamivudine phase Ⅳ clinical trials completed the SF-36 assessments at baseline, 26 weeks and 52 weeks. Results Patients with chronic hepatitis B on lamivudine showed an improvement in quality of life in several domains such as role physical (RP 9.6), social function (SF 8.2) , role emotional (RE 11.8), vitality (VT 6.2) over 6 and 12 months compared to baseline especially concentrated in mean mental components (MCS 3.6).Conclusion Patients with chronic hepatitis B have significant improvement in quality of life after treatment with lamivudine.更多还原