【摘要】 目的　探讨抗心磷脂抗体 (ACLA)、D 二聚体 (D D)的水平与脑血栓的关系。方法　以ELISA方法检测 4 5例脑血栓患者血清ACLA及血浆D D水平 ,同时检测 4 4例健康体检者为对照组。结果　脑血栓患者血浆D D水平为(2 .4 0± 0 .6 10 )mg/L ,明显高于正常对照组的D D水平 (0 .4 2± 0 .0 3)mg/L ,t =12 .976 ,P <0 .0 1,血清ACLA的平均结合指数 (BI)显著高于正常对照组 (tIgG　 =5 .95 3,tIgM　 =6 .5 32 ,tIgA　 =9.0 90 ,P 均小于 0 .0 1) ,且与血浆D D的水平呈明显正相关性 (rIgG　 =0 .6 0 0 ,rIgM　 =0 .5 5 2 ,rIgA　 =0 .4 72 ,P均小于 0 .0 1)。脑血栓患者IgG ACLA的阳性率达 75 .6 % ,IgM ACLA的阳性率达 6 8.9% ,具有一型以上阳性者的比率为 6 4 .4 % ,而正常对照者却仅一例阳性 ,二者比较有显著性差异 (P <0 .0 1)。结论　ACLA水平的升高与脑血栓形成关系密切 ,ACLA水平的升高可能是引发脑血栓的重要原因 ,而D D水平的升高说明脑血栓患者的继发纤溶功能亢进 ,在凝血系统激活的同时 ,纤溶系统也被激活。更多还原

【Abstract】 Objective To study the correlation between d-dimer,anticardiolipin antibodies and cerebral thrombosis.Methods To measure the levels of plasma d-dimer and serum anticardiolipin antibodies in 45 patients with first cerebral thrombos is and 44 healthy control subjects with Enzyme linked immunosorbent assay (ELISA).Results The level of plasma d-dimer in patients with cerebral thrombosis was significantly elevated than the healthy subjects( t =12.976, P <0.01).The median bound index of anticardiolipin antibodies in patients with cerebral thrombosis was significantly elevated than the healthy subjects( t _ IgG =5.953, t _ IgM = 6.532 , t _ IgA =9.09, P <0.01)).The correlation between plasma d-dimer and serum anticardiolipin is significant( r _ IgG =0.600, r _ IgM =0.552, r _ IgA =0.472, P <0.01).The positive rates of anticardiolipin antibodies between cerebral thrombosis and healthy subjects is significantly different( P <0.01).Conclusion ACLA has an obvious correlation with cerebral thrombosis and it may be the reason of cerebral thrombosis.The elevated level of plasma d-dimer in patients with cerebral thrombosis demonstrates that cerebral thrombosis patients has secondary hyperfibrinolysis,as well as the activation of coagulation.更多还原