【摘要】 目的　探讨PT、HPT、FⅦ :C、TAT 4项指标在急性肝炎患者测定中的临床意义及方法学评价。方法　急性肝炎住院患者 2 6例 ,同步检测PT、HPT、FⅦ :C、TAT 4项指标 ,并分别与 90例正常人测定结果相比较。结果　急性肝炎患者 4项指标测定结果与正常对照组相比较 ,差异均有显著意义 (P <0 .0 5～ <0 .0 0 1) ;4项指标的灵敏度依次为19%、2 7%、38% ,77% ;TAT均值高出正常组 4倍 ,其特异性为 97%、阳性预期值为 87%、阴性预期值为 94 % ,均高于PT、HPT和FⅦ :C 3项指标。结论　 4项指标均有助于临床判断急性肝炎的严重程度。TAT异常出现得早 ,敏感性最好 ,发病早期诊断最优。更多还原

【Abstract】 Objective To study the clinical significance of testing four indicators PT,HPT,FⅦ:C and TAT and methodology evaluation in acute hepatitis patients.Methods Four indicators were tested simultaneously in 26 cases of acute hepatitis inpatients and the results were compared with 90 cases of normal control group.Results A significant change of all four indicators was observed in acute hepatitis( P <0.05～<0.001);The sensitivity is 19%,27%,38%and 77% respectively for four indicators, and average TAT value is four times higher than that of normal control group.The specificity,predictive values of positivity and negative for TAT is 97%、87% and 94% respectively, which is higher than PT,HPT and FⅦ:C.Conclusion The four indicators are all helpful in determining the severity of acute hepatitis. The indicators are more sensitive when TAT abnomaly occurs in early stage of disease. As a result, better diagnosis could be achieved.更多还原