【摘要】 本试验研究单剂量静脉注射、肌肉注射和乳房灌注恩诺沙星 (2 .5 mg/kg)在健康奶山羊的药动学及乳中药物浓度。采用 HPL C法测定血浆和乳中恩诺沙星及其代谢产物环丙沙星的浓度 ,用统计矩原理处理血浆中药物浓度 -时间数据 ,计算非房室模型的药动学参数。静脉注射、肌肉注射和乳房灌注恩诺沙星的 t1 /2β分别为 1.3 2、1.5 5、0 .99h;AU C为 1.0 6、3 .0 4、2 .66mgh L- 1 ;恩诺沙星的代谢分数为 3 5 .0 1%、44 .0 6%、45 .73 % ;环丙沙星的 t1 /2β为 1.81、2 .94、2 .3 2 h。乳中的药物浓度高于同期血中药物浓度 ,且乳中环丙沙星浓度高于恩诺沙星浓度并维持更长的时间更多还原

【Abstract】 The single dose pharmacokinetics of enrofloxacin were studied in healthy lactating goats after intravenous (iv), intramusuclar(im) and intramammary (imm) administration of the drug at dose of 2.5 mg/kg. The concentrations of enrofloxacin and its metabolite ciprofloxacin in plasma and milk were determined by HPLC method and the concentration time data were subjected to statistical moments to compute the non compartmental model pharmacokinetic parameters. The mean elimination half lives(t 1/2β )of iv, im and imm were 1.32?1.55?0.99 h;area under concentration time curve (AUC)were 1.06?3.04? 2.66mghL -1 ;metabolic rates of enrofloxacin were 35.01%?44.06%?45.73%; and the t 1/2β of ciprofloxacin were 1.81?2.94?2.32 h,respectively. the concentrations of the two drugs in milk were higher than those in plasma concurrently, ciprofolxacin showed higher concentrations in milk and maintained longer period than enrofloxacin did.更多还原