【摘要】 【目的】探讨癌组织内MVD及VEGF表达与子宫内膜癌预后的关系。【方法】以SP免疫组化法检测48例子宫内膜癌组织MVD及VEGF的表达,分析其与预后的关系。【结果】Kaplan-Meier曲线法生存分析显示MVD≥10者的生存率较MVD<10者的明显降低,差异有统计学意义,P<0.05;VEGF表达强度与患者生存率无显著性相关。Cox回归分析显示MVD是子宫内膜癌的独立预后因素,RR=4.02,P<0.05。【结论】高水平MVD者的预后较低水平MVD者差,MVD是子宫内膜癌的独立预后因素之一。更多还原

【Abstract】 Objective] To investigate the relationships between intratumor MVD, VEGF expression and the prognosis of patients with endometrial carcinoma. MVD and VEGF expression in endometrial carcinoma tissue were detected by SP immunohistochemical method in 48 patients. The relationships between MVD, VEGF expression and prognosis were analyzed. Kaplan Meier survival analysis showed that survival rate in patients with MVD≥ 10 was significantly lower than that with MVD< 10.P< 0.05. No significant correlation was found between VEGF expression and survival rate. Cox regression analysis showed that MVD was an independent prognostic factor for endometrial carcinoma. RR was 4.02, P< 0.05. [ Conclution] High level of MVD is associated with poor survival of patients with endometrial carcinoma. MVD is one of the independent prognostic factors for endometrial carcinoma.更多还原