【摘要】 林可霉素(lincomycin,洁霉素)是由链霉菌(streoptomyces lincolnensis)产生的一种碱性抗生素,我国临床使用量比较多,临床使用时间比较久,目前,滥用、超剂量用药现象比较普遍,不良反应日益严重。其主要不良反应包括神经系统损害、泌尿系统损害、呼吸系统损害、心律紊乱、再生障碍性贫血、视觉损害、伪膜性肠炎,严重者可引起休克。本文综述了林可霉素的化学性质、生物学特性、药代动力学、药物剂型和剂量、临床应用和不良反应。更多还原

【Abstract】 Lincomycin is a kind of alkalescent antibiotic, originated from streoptomyces lincolnensis. In China, itsapplied at large amount in clinical steatment, and its applied in clinic for a long time. At present, drug abusing andover-dosage prescribing is in common , and adverse reaction is more and more serious. Its main adverse reactionincludes functional impairment of neurological system, urinary system, respiratory system, cardial archythymia,aplaslicanemia, vision impairment, pseudomembranous colitis, and even shock. This article reviews lincomycin,schemistrical character, biological feartue, pharmacokinetics, and dosage forms and dosage, clinical application andadverse reaction.[更多还原