【摘要】 信号转导是当前分子生物学研究的热点领域。信号转导和转录激活蛋白STAT3被许多细胞因子和生长因子激活而介导多种生理过程。STAT3蛋白含有DNA结合域 ,SH2区和转录激活区等保守区域 ,通过 70 5位酪氨酸的磷酸化而激活 ,形成二聚体 ,入核与特异DNA元件结合 ,启动靶基因的转录。STAT3在神经系统的发育过程中有表达 ,并与其他信号途径协同调节体内神经前体细胞的分化命运 ,STAT3结合元件的甲基化状态还决定了细胞的分化潜能。此外 ,STAT3蛋白还参与维持神经细胞的存活和促进神经损伤后的再生。更多还原

【Abstract】 Signal transduction is the hotspot of current molecular biology. Signal transducer and activator of transcription 3 (STAT3)is activated by various cytokines and growth factors and involved in multiple physiological processes. STAT3 proteins have conservative domains including DNA binding-domain,SH2 domain and transcription activation domain. STAT3 proteins are activated by tyrosine phosphorylation at Tyr705,then form dimmers,translocate to the nucleus,and bind to specific DNA-response element of target genes to induce gene transcription. STAT3 is expressed during the development of nervous system,and regulates the differentiation of neural progenitor cells with synergistical contribution of other signaling cascades. The methylation status of STAT3 binding element also determines cell lineage specification. STAT3 protein also plays important roles in maintaining nerve cells survival and promoting their regeneration after injury.更多还原