【摘要】 目的 探讨PTEN、FAK与Ki67在胶质瘤增殖、侵袭过程中的相互作用。方法 应用SP免疫组化法检测了50例不同级别胶质瘤中的三种蛋白表达情况。结果 不同级别的胶质瘤中PTEN、FAK与Ki67的表达水平不同,Ⅱ级与Ⅲ、Ⅳ级肿瘤之间三者表达差异显著;PTEN与FAK、Ki67在胶质瘤中的表达呈负相关。结论提示PTEN表达缺失可引起FAK及Ki67的过表达,从而加强胶质瘤的增殖和侵袭。更多还原

【Abstract】 Objective To study the interaction of PTEN, FAK and Ki67 in the proliferation and invasion of human gliomas.Methods The SP immunohistochemical method is used to measure the expression of those proteins in 50 gliomas with different grades.Results Expressions of these proteins are varied among different malignancy grading of gliomas. The differences of expression level among grade Ⅱ , grade Ⅲ and Ⅳ were statistically significant; PTEN expression was negatively correlated with the expression of Ki67 and FAK. Conclusions Inactivation of PTEN will lead to the overexpression of Ki67 and FAK, and promotes the prolieration and invasion of gliomas.更多还原