【摘要】 在不使用有机溶剂和乳化剂情况下,利用反应条件温和且无毒的多价反离子对阳离子多糖的凝胶化诱导作用,制得可用于治疗药物输送的可生物降解亲水性纳米载体。通过优化反应参数,可使所得多糖凝胶微粒平均粒径介于20～100nm之间。更多还原

【Abstract】 In order to develop hydrophilic nanoparticulate carriers for the administration of therapeutic drugs, biodegradable nanoparticles were prepared by inducing the gelation of a cationic polysaccharide with gentle and nontoxic multivalent counterions in the absence of organic solvents and emulsifiers. By optimizing the reaction parameters, the polysaccharide_gel nanoparticles in the average size range from 20～100 nm were obtained. 更多还原