【摘要】 目的 :探讨血清及胆汁中IL 6水平与胆囊炎和胆囊癌的关系。方法 :应用ELISA方法测定 15例急性胆囊炎、15例慢性胆囊炎和 10例胆囊癌患者及 3例正常对照者的血清及胆汁中的IL 6水平。结果 :急性胆囊炎患者血清和胆汁IL 6水平显著高于胆囊癌、慢性胆囊炎患者和正常对照者 (均P <0 .0 1) ;胆囊癌患者胆汁IL 6水平显著高于慢性胆囊炎患者和正常对照者 (均P <0 .0 5 )。结论 :急性胆囊炎患者血清IL 6水平升高反映了胆囊炎的全身炎症反应程度 ,胆汁IL 6水平升高反映了胆囊局部炎症反应程度。胆汁IL 6可能作为胆囊癌的肿瘤标记物应用于临床诊断。更多还原

【Abstract】 Objective:To reveal the values of IL 6 in serum and bile in relation to cholecystitis gallbladder carcinomas.Methods:Using the technique of ELISA,the values of IL 6 in serum and bile in the patients with acute cholecystitis (15 cases), chronic cholecystitis (15),gallbladder carcinoma(10) and normal case (3) were determined respectively.Results:The values of IL 6 in serum and bile in the patients with acute cholecystitis were obviously higher than that in the patients with carcinomas, chronic cholecystitis and normal cases ( P <0.01). The values of IL 6 in bile in the patients with carcinomas were obviously higher than that in the patients with chronic cholecystitis and normal cases ( P <0.05).Conclusion:The increased level of IL 6 in serum reflects the degree of systemic inflammatory reaction of the patients with acute cholecystitis;whereas the increased elevel of IL 6 in bile reflects the degree of local inflammatory reaction of gallbladders. IL 6 could be used as tumor markers in the diagnosis of gallbladder carcinomas.更多还原