【摘要】 目的 :通过研究高强度聚焦超声 (highintensityfocusedultrasound ,HIFU)扫描损伤离体人子宫肌瘤的能效关系 ,寻找HIFU扫描损伤子宫肌瘤的适宜参数。方法 :不同声强及辐照时间的HIFU(频率 0 .8MHz,焦距 117mm ,声强 0～ 85 87.6W /cm2 )在相同的扫描线长下对同一焦点深度的离体人子宫肌瘤组织进行扫描损伤 ,记录不同声强造成组织损伤的阈扫描时间并计算其损伤灶体积及能效因子。结果 :在相同的声强下 ,损伤体积随辐照时间的延长而增加 ,阈扫描时间随声强的增加而减少 ,能效因子随声强及扫描时间不同而发生变化 ,随着声强的增大 ,最佳能效关系点出现后移 ,焦点声强为 5 76 2 .7W /cm2 时其阈扫描时间 (4 5s)为出现最佳能效因子所需的扫描时间。结论 :HIFU以 15mm线长进行扫描损伤子宫肌瘤时 ,焦点声强5 76 2 .7W /cm2 、扫描时间 4 5s是适宜的治疗参数。更多还原

【Abstract】 Objective:To explore the dose-effect on ablation of human uterine myoma with HIFU scanning and find a suitable exposure parameters for HIFU ablation of uterine myoma in vitro.Methods:An extracorporeal HIFU transducer with a frequency of 0.8 MHz,intensity 0～8587.6W/cm 2 and focal length of 117mm was used.Thirty-one human uterine myoma specimens were sonicated by ultrasound with different intensity and exposure time.The threshold time and lesion size were determined and the energy efficiency factor was calculated.Results:It was found that under the same intensity,the lesion size increased with exposure time,while the threshold time decreased with the intensity.The energy efficiency factor was related to intensity and exposure time,and it was optimal under the threshold time (45s) when focal intensity was 5762.7W/cm 2.Conclusion:While using the scanning line of 15mm,the suitable exposure parameters for HIFU ablation of uterine myoma was 45 seconds for scanning lesion with focal intensity of 5762.7W/cm 2更多还原