【摘要】 目的 :研究多原发乳腺癌组织P - gp和nm2 3、P5 3变化规律 ,探讨P - gp和nm2 3、P5 3与多原发癌发生的关系 ,方法 :应用免疫组化检测 34例良恶性乳腺组织中P - gp、nm2 3、P5 3的表达 ,并比较其阳性表达率和程度的差异。 结果 :多原发乳腺癌和无复发乳腺癌组织P5 3阳性表达率均较乳腺纤维腺瘤组织高 ,多原发乳腺癌P5 3阳性表达程度高于无复发乳腺癌。结论 :P5 3可反映癌组织细胞增殖活性 ,P5 3过表达预测第二原发癌发生具有一定价值。更多还原

【Abstract】 Objective: To study the expression of P-gp and nm23,P53 in multiple primary breast carcinoma tissues and to evaluate the prediction significance in occurrence of the second primary carcinoma. Methods:Expression of P-gp,nm23,P53 in 34 benign and malignant breast paraffin-embedded specimens, the difference of the rate and the intensity of positive reaction of P-gp,nm23,P53 were checked.Results:The positive rate of P53 was significantly increased in malignant breast tissues compared with benign breast tissues,the positive intensity of P53 was significantly increased in multiple breast carcinoma tissues compared with the tissues of no occurrence of breast carcinoma. Conclusion:The expression of P53 may indicate the proliferating activity of carcinoma cell. The positive intensity of expression of P53 can be certain valuable in prediction of the occurrence of second primary carcinoma.更多还原