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头孢地尼治疗36例皮肤软组织感染临床疗效及抗菌活性观察

Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections

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【作者】 曾爱中辛小娟肖永红陈海

【Author】 ZENG Aizhong,et al (Department of Infectious Diseases,College of Clinical Medicine,Chongqing Medical University)

【机构】 重庆医科大学临床学院感染科重庆医科大学临床学院感染科 重庆400016重庆400016重庆400016

【摘要】 目的 :以头孢地尼和头孢特仑酯随机对照治疗急性皮肤、软组织感染 ,评价头孢地尼的疗效及安全性。方法 :18例患者接受头孢地尼 10 0~ 2 0 0mg ,每日 3次 ;18例接受头孢特仑酯 10 0~ 2 0 0mg ,每日 3次 ,疗程 7~ 14天。 结果 :试验组和对照组痊愈率和有效率分别为 77.8%、72 .7% (P >0 .0 5 )与 94 .4 %、88.9% (P >0 .0 5 )。两组的细菌阳性率、清除率分别为 83.3%、88.9% (P >0 .0 5 )和 93.3%、87.5 % (P >0 .0 5 )。临床分离的 31株致病菌对头孢地尼、头孢特仑酯、头孢克肟、头孢克洛、阿莫西林和环丙沙星的敏感率分别为 10 0 %、10 0 %、6 7.8%、86 .5 %、6 2 .3%和 6 6 .1% ;头孢地尼与头孢特仑酯、头孢克洛相比差异无显著性 (P >0 .0 5 ) ,但与头孢克肟、阿莫西林和环丙沙星相比差异有显著性 (P <0 .0 5 )。两组不良反应发生率分别为 0和 6 .2 5 % (P >0 .0 5 )。结论 :头孢地尼治疗轻、中度细菌感染安全、有效。

【Abstract】 Objective: To evaluate the clinical efficacy and safety of cefdinir in the treatment of mild and moderate skin and soft tissue bacterial infections. Methods: 18 patients in study group were treated with cefdinir 100~200mg per oral three times a day and 18 patients in control group with cefteram pivoxil 100~200mg per oral three times a day for 7 to 14 days. Results: The cure rates and the effective rates of the two groups were 77.8%,72.7% (P>0.05) and 94.4%,88.9% (P >0.05),respectively.The bacterial positive and eradication rates of the two groups were 83.3%,88.9% (P >0.05) and 93.3%,87.5% (P >0.05),respectively.Sensitivity rates of 31 bacterial strains to cefdinir,cefteram pivoxil,cefixime,cefaclor,amoxacillin and ciprofloxacin were 100%,100%,67.8%,86.5%,62.3% and 66.1%,respectively.Adverse events rates of the two groups were 0.0% and 6.25%,respectively.No significant statistic difference was detected between the two groups. Conclusion: The efficacy and safty of cefdinir in the treatment of mild and moderate skin and soft tissue bacterial infections is reliable.

  • 【文献出处】 重庆医科大学学报 ,Acta Universitatis Scientiae Medicinae , 编辑部邮箱 ,2003年02期
  • 【分类号】R969
  • 【被引频次】14
  • 【下载频次】171
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