【摘要】 目的　探讨乳腺良恶性疾病的C met蛋白表达及微血管密度 (MVD )与乳腺癌预后的关系。方法　采用免疫组化SP法检测C met蛋白及MVD ,标本取自已确诊的 70例乳腺癌和 2 0例乳腺增生症患者 ,结果　C met的染色定位主要在乳腺良性增生上皮及乳腺癌上皮的细胞浆及膜。良性乳腺增生症的C met蛋白表达为 10 0 % ,乳腺癌为 78.6%。在乳腺癌细胞中C met的表达染色强度高于乳腺增生症 ,但差异无显著性 ;乳腺癌Ⅲ期的染色强度明显高于Ⅰ和Ⅱ期。C met阳性表达患者的生存率低于阴性患者。C met表达阳性组织有较高的微血管密度 ,而微血管密度高的患者生存率较低。Cox回归分析C met和微血管密度均是预后因素。结论　C met在良恶性乳腺疾病中均有表达 ;C met和微血管密度与乳腺癌患者的TNM分期、生存率关系密切。二者均可作为是有价值的预后指标。更多还原

【Abstract】 Objective To determine the expression of C met protein and microvessel density (MVD) in benign and malignant breast diseases and the relation with the prognosis of the patients. Methods Expression of C met and MVD were detected by immunohistochemical SP method in the histologic sections of 20 benign hyperplasia patients and 70 breast cancer patients. Results Stain of C met was located in the membrane or cytoplasm of epithelia cells.In the benign breast hyperplasia, C met expression was 100%. The stain intensity in breast cancer was stronger than that in the benign hyperplasia, but not statistical significance. The expression of C met was higher in TNM stage Ⅲ cancer than that in stage ⅠandⅡcancer. The stronger expression of C met showed higher MVD and obviously lower survival rate . Coxregression indicated C met and microvessel were prognosis factors. Conclusions C met is expressed in benign and malignant breast disease, C met and MVD are related with survival rate of breast cancer patients , so they are valuable prognosis indicators of breast cancer patients.更多还原