【摘要】 目的　探讨腹壁切口感染对腹腔粘连形成的影响。方法　将 12 0只Wistar大鼠分为低、中、高浓度组和对照组 ,每组各 3 0只 ,前 3组动物分别按 1× 10 2 cfu/ml、1× 10 5 cfu/ml、1× 10 8cfu/ml的浓度将大肠埃希氏菌、金黄色葡萄球菌和铜绿假单胞菌的定量混合液 0 .2ml分别注入切口皮下 ,对照组注入等量生理盐水 ,建立腹部切口感染的动物模型。术后第 8天处死动物 ,观察和比较 4组动物的切口粘连情况。结果　低、中、高浓度组和对照组的切口感染率分别为 81.48%、86.67%、90 .0 0 %和 50 .0 0 % ;粘连率分别为 53 .3 3 %、60 .0 0 %、70 .0 0 %和 2 6.67% ,经 χ2 检验 ,低浓度组与对照组腹腔粘连发生率的差异有显著性意义 (P<0 .0 5) ,中、高浓度组和对照组比较差异有高度显著性意义 (P均 <0 .0 1) ;而低、中、高浓度组之间的腹腔粘连率比较差异则无显著性意义 (P>0 .0 5)。结论　腹壁切口感染可使腹膜粘连的发生率增高 ,而与细菌的数量没有明显的关系。提示腹部手术切口感染也是形成腹腔粘连的一个原因更多还原

【Abstract】 Objective To study the influence of i nfection in incision of abdominal wall on peritoneal adhesion. Methods One hundred and twenty white rats were divided into low, medium, high concentration (LC, MC, HC) groups and control gr oup, 30 rats each, and were made animal models of abdominal incision infection, then were respectively given hypodermic injections in incisional wound of 0.2 ml quantitative mixture of Escherichia coli, staphylococcus aureus and pseudomonas aeruginosa in the concentration of 1×10 2, 1×10 5 and 1×10 8 cfu/ml. Whil e the control group,normal saline was given. All the subjects were killed 8 days after operation and compared the peritoneal adhesion among the four groups.Results Infection rate of the incisional wounds was 81.48%, 86.67%, 90.00% and 50.00% respectively in LC, MC, HC and the control, peritoneal a dhesion rate was 53.33%, 60.00%, 70.00% and 26.67% respectively. There was significant differen ce between LC and the control ( P <0.05), between MC or HC and the control ( P <0.01 ). While no difference was among LC, MC and HC ( P > 0.05).Conclusion Infection of incision may increase peritoneal adhesion which might not be closely related to the number of the bact eria. This suggests that the prevention of infection plays an important role in preventing peritoneal adhesion.更多还原