节点文献

紫苏子镇咳、祛痰、平喘作用的药理研究

Antitussive, expectorants and antiasthmatic effects of Perilla frutescens

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 王永奇邢福有刘凡亮张巍峨乌兰姜丽张学梅梁文波赵红吴丽霞付子栋

【Author】 Wang Yong-qi , Xing Fu-you. Liu Fan-liang . Zhang Wei-e , Wu Lan , Jiang Li, Zhang Xue-mer , Liang Wen-bo , Zhao Hong , Wu Li-xia , FU Zi-dong (1. Bioengineering Institute of Dalian University , Dalian 116622; 2. Medical School of Dalian University, Dalian 116622: 3. Pharmacy Department of Kanazawa University, Japan)

【机构】 大连大学生物工程学院大连大学医学院药理教研室日本·金澤大学药学部·天然医药分子化学研究室日本·金澤大学药学部·天然医药分子化学研究室 大连 116622大连 116622大连 116622

【摘要】 目的 对紫苏子及其炮制品的梯度溶媒提取物进行了镇咳、祛痰、平喘的对比性研究。方法 浓氨水喷雾法、毛细玻管法、喷雾致喘法。结果 1.紫苏子水提物、醇提物和醚提物均显示了程度不同的镇咳作用。2.紫苏子和炒紫苏子水提物的小剂量组均有良好的祛痰作用。3.对4%氯化乙酰胆碱诱导的豚鼠哮喘未发现其有平喘作用。但对用2%氯化乙酰胆碱和0.1%磷酸组胺的等量混合液诱喘的哮喘模型,炒紫苏子水提物和醚提物的小剂量组都显示出显著的平喘效果。结论 紫苏子具有一定的镇咳、祛痰和平喘作用,其镇咳成分较分散。平喘成分的水溶性大。存在于炒紫苏子的平喘成分其极性较分散.既存在于极性大的部分也存在于极性小的部分。

【Abstract】 OBJECTIVE To determine the antitussive, expectorant and antiasthmatic effects of extracts of Perilla frutescens. METHODS Nehulixation of strong ammonia, method of capillary and asthmogenic method by nebulization were used. RESULTS 1. The water, alcohol and ether extracts of Perilla frutescens showed different antitussive effects. 2. The water extraction of Perilla frutescens and parch Perilla frutescens implied expectorant effects at low concentration. 3. Both water extraction and ether extraction of parch PS displayed obvious antiaslhmatic effect on the asthma model when 2% acethylcholine chloride and 0. 1 % histamine phosphate were used as asthmogenic drug, but no antiasthmatic effect on the model when 1% acecolex was used as the asthmogenic drug. CONCLUSIONS The antitussive, expectorant and antiasthmatic effects of Perilla frutescens were confirmed in our experiments. The polarity of antitussive elements in Perilla frutescens is dispersive. The polarity of expectorant elements in Perilla frutescens is strong, and its water-solubility is also strong. The antiasthmatic elements in parch Perilla frutescens are dispersive. They exist in parts of both strong and weak polarity.

【关键词】 紫苏子镇咳祛痰平喘
【Key words】 Perilla frutescens antitussiveexpectorant: antiasthmatic
【基金】 国家科技部“九五”攻关项目;国家自然科学基金项目(30171140)
  • 【文献出处】 中南药学 ,Central South Pharmacy , 编辑部邮箱 ,2003年03期
  • 【分类号】R285
  • 【被引频次】164
  • 【下载频次】1372
节点文献中: 

本文链接的文献网络图示:

本文的引文网络