【摘要】 目的 :为评估国产万拉法新治疗抑郁症的疗效、不良反应及安全性。方法 :通过随机双盲双模拟和临床多中心实验。采用HAMD和TESS在用药前及用药后 7、14、2 8、4 2d评定药物疗效与不良反应。结果 :国产万拉法新对抑郁症的整体疗效与多虑平相当 ,但能较快控制症状 [一周内 ]。在TESS中 ,植物、心血管、神经系统等因子评分均显著低于多虑平 ,且常见副作用 ,如口干、便秘、失眠、多汗、头晕、恶心等大部分无须处理。结论 :国产万拉法新是一种耐受性较好的新型抗抑郁药。更多还原

【Abstract】 Objective:To study the effect,adverse events and safety of Venlafaxine(made in China)that treated depression.Method:Random double blind and double several center test in clinic.The efficacy was measured with Hamiltom depression scale HAMD.The side effects were determined by the treatment emergent symptom scale TESS.The two all test before and after 7?14?28?42d.Result:Venlafaxine(made in China)complete efficacy are as much as Doxepinum in treatment depression.But it effects rapidly(in a week).In TESS,Autonomice,heart function,nervous and so on were significantly lower in the Doxepini group.The adverse events:Dry mouth,constipation,insomnia,sweating,dizziness,nausea need not treat.Conclusion:Venlafaxine(made in China)is a better antidepressant of well tolerated than others.更多还原