【摘要】 目的　探讨血管紧张素转化酶 ( ACE)及血管紧张素 - 1型受体 ( AT1 R)基因多态性与原发性高血压 ( EHT)的关系。方法　应用聚合酶链反应及 PCR加酶解方法检测 1 50例健康人 ( NT)及 1 52例 EHT患者 ACE I/ D基因多态性的 ACE及 AT1 R A1 1 6 6 C突变。结果　 EHT组ACE I/ D基因多态性等位基因频率 I为 0 .50 ,D为 0 .50 ,D等位基因频率及基因型频率显著高于 NT组 ( P<0 .0 5) ;而两者之间的 AT1 R A1 1 6 6 C的C等位基因频率差异无显著性 ( P>0 .0 5)。结论　 ACE基因可能是 EHT的重要遗传因素 ,AT1 R基因 A1 1 6 6 C多态性与 EHT无关更多还原

【Abstract】 Objective To identify the I/D polymorphism of angiotensin converting enzyme (ACE) and A116 6C polymorphism of angiotensin II type I receptor (AT1R) genes in patients with essential hypertension.Methods ACE and AT1R genotyping wi th polymerase chain reaction (PCR) and PCR combined with restriction enzyme dige stion were used to detect ACE gene I/ D polymorphism and AT1 R gene A1166C vari ations in 150 hypertensive subjects and 152 controls.Results The frequencies of frequencies of the ACE D allele in EHT groups of were hig her than that in the health controls, respectively (P<0.05). But there was n o significant difference in the frequency of AT1R C allele between the two group s of EHT and NT(P>0.05).Conclusions ACE gene contribu tes to the development of essential hypertensive, but AT1R gene is not associate d with hypertension. not to the incidence of BI in the hypertensive, polymorphis m in the gene for the angiotensin II type 1 receptor更多还原