【摘要】 目的　探讨细胞因子在老年肺间质纤维化 ( IPF)发病中的作用及甲基强地松龙对肺间质纤维化病人肿瘤坏死因子 - α( INF- α)及白细胞介素 8( IL- 8)的影响。方法　用酶联免疫法 ( IL ISA)检测甲基强地松龙治疗前后的 1 0例老年肺间质纤维化病人的血清及支气管肺泡灌洗液( BAL F )的变化并与 1 0例非肺间质纤维化健康老年人对照。结果　肺间质纤维化病人的血清及 BAL F中 TNF-α及 IL - 8明显高于正常人 ( P<0 .0 5)。甲基强地松龙治疗后病人的 TNF-α及 IL - 8均明显下降 ( P<0 .0 1 )。 IPF组中 ,BAL F中 TNF -α及 IL - 8的表达皆与中性粒细胞呈正相关 (γ=0 .831 ,P<0 .0 1 ;γ=0 .885,P<0 .0 1 )。结论　 TNF -α及 IL - 8在肺间质纤维化发病中起重要作用 ,甲基强地松龙抑制其表达。更多还原

【Abstract】 Objective To study the r ol e of cytokines released by immunocytes from pathogenesis of old patient with IPF and the influence of Solu-MedrolTM on TNF-α and IL-8 of IPF.Meth ods with allergy immunology, the levels of TNF-α and IL-8 was mea sured in the serum and BALF of 14 old patients with IPF subjects before and afte r therpy with solu-MedrolTM, and controlled with 10 normal old subjects. Results The levels of TNF-α and IL-8 in the serum and BALF of patients with IPF were significantly higher than these in control group (P< 0.05). The levels of TNF- and IL-8 were significantly lower after the IPF pati ents were therapied with solu-MedrolTM (P<0.01), Expression of TNF-α and IL-8 in BALF as positively related to the level of neutrophilin BALF. (r=0. 831, P<0.01, r=0.885,P<0.01). Conclusions TNF -αand IL-8 have important effects on IPF; Solu-MedrolTM can suppress their e xpression.更多还原