【摘要】 目的　观察补肾煎对去势高脂血症兔血 ox- LDL水平以及内皮细胞 ox- L DL m RNA表达的影响。方法　纯种新西兰雌兔去势术 +0 .5%胆固醇饲料 +静注牛血清白蛋白造模 ,模型动物连续使用雌激素和补肾煎治疗 1 2 w后检测相关指标。结果　与模型组相比 ,补肾煎较好地降低 ox- L DL含量 (P<0 .0 5) ,减少内皮细胞 ox- LDL m RNA的表达 (P<0 .0 5)。结论　补肾煎可改善去势高脂血症模型兔异常的血 ox- LDL水平 ,减少内皮细胞 ox- L DL m RNA的表达 ,从而减少 LDL氧化修饰 ,保护内皮细胞功能、防治绝经后动脉粥样硬化。更多还原

【Abstract】 Objective Effect of BU SHEN JIAN, the kidney tonifying recipe of traditional Chinese medicine, on plasma ox LDL and the expression of ox LDL mRNA of endothelia cell were observed in experimental castrated hyperlipidemia rabbits Methods All the rabbits were fed high cholesterol diet after the castration operation and injected bovine serum albumin The kidney tonifying recipe was given for 12 weeks Results Kidney tonifying recipe could decrease the level of prevent the rising of plasma ox LDL ( P <0 05), and the expression of ox LDL mRNA of endothelia cell ( P <0 05) Conclusions The kidney tonifying recipe "BU SHEN JIAN" possesses the effect of decreasing the level of ox LDL, and the expression of ox LDL mRNA, and thus preserves the function of endothelial cell as well更多还原