【摘要】 目的　通过动物实验研究探讨一种有效的溶栓治疗急性脑梗死。方法　对三组犬分别给予静脉溶栓 (IV)、动脉溶栓 (IA)及静脉 +动脉联合溶栓 (IV +IA) ,并与对照组对照 ,并获取相关的DSA资料、病理标本。结果　动物实验 (IV组 ) 1例部分再通 ,(IA组 ) 4例部分再通 ,IV +IA组 3例部分再通 ,3例完全再通 ,再通犬梗死灶面积明显小于对照组 (P <0 0 0 1 ) ,IV +IA组明显小于IA组及IV组 (P <0 0 0 1 )。结论　本动物模型建立方法成功率高 ,梗死灶稳定 ,重复性好 ;IV +IA溶栓优于其他方式。更多还原

【Abstract】 Objective To explore a most effective thrombolysis method.Methods Dogs are chosen as research targets.They were divided into three groups: IV, IA, IV+IA.Each group was compared with the control group.The DSA data and pathologic specimen were evaluated.Results The number of partial recanalization case of IV group is one, that of IA group are four and that of IV+IA group are three.That of complete recanalization of IV+IA group are three.The infarction area of recanalization cases are significantly smaller than that of control group ( P <0.001).The infarction area of IV+IA group are significantly smaller than that of IV and IA group( P <0.001).Conclusions This animal model construction method has high success rate, steady infarction and can be repeated easily.IC+IA thromolysis is better than other methods.更多还原