【摘要】 目的　探索不同剂量的大豆异黄酮 (isoflavones ,IFs)和维生素C(VC)、维生素E(VE)混合干预物对老年 2型糖尿病 (2 DM)病人糖负荷后血液中粘附分子 (adhesionmoleculesAMs)表达的影响。方法　随机将 1 1 5例已确诊的老年 2 DM病人分为空白 (B组 )、低剂量 (C组 )、中间剂量 (D组 )和高剂量 (E组 )的大豆异黄酮和VC、VE混合干预物组 ,与正常人对照 (A组 )比较 ,观察各组糖负荷 (OGTT)前、后AMs的表达。结果　OGTT中 ,A组、B组和C组血液中可溶性细胞粘附分子 1 (sICAM 1 )、E 选择素 (E selectin)都显著增高 ,而D组、E组无这种现象 ,两组间无显著差异。结论　高血糖可产生过氧化应激而引起血液中AMs的过度表达。由 1 50mgIFs和 50 0mgVC、40 0IUVE组成的混合干预物 (每日顿服剂量 ) ,可作为 2 DM人群以防治动脉粥样硬化 (atherosclerosis,AS)等并发症为目的的推荐摄入量。更多还原

【Abstract】 Objective To investigate the effect of different dosages of antioxidant (Isoflavone, Vitamin C and E) on the expression of adhesion molecules(AMs) in senior type 2 diabetes mellitus patients (2-DM) patients.Methods Forty diagnosed 2-DM patients were randomly divided into zero dosage control group(B), low dosage group(C), medium dosage group(D) and high dosage group(E) with mixture of soy isoflavone, vitamin C and vitamin E, comparing with normal blood glucose control group(A), to observe the effect on expression of adhesion molecules during the OGTT procedure.Results During OGTT, sICAM-1 and E-selectin were found increased in group A, B and C, but not in group D or E ( P <0.05).Conclusions Glycemia can induce the over-expression of AMs due to oxidant.It was recommended to prevent 2-DM complications such as atherosclerosis with the mixture at the dosage of 150 mg soy isoflavone and 500 mg vitamin C and 400 IU vitamin E.更多还原