【摘要】 目的:探讨SPA对肺癌增殖的抑制作用并探讨其机制。方法:采用体外细胞培养以及小鼠动物模型,观察SPA对培养肿瘤细胞的抑制,及其对小鼠动物模型肿瘤增殖、免疫及白介素1和2产生的影响。结果:SPA在20,40,80mg/kg的剂量下连续灌胃给药10d,对小鼠体内Lewis肺癌生长具有明显抑制作用,生长抑制率分别为35.27％(P<0.01),48.29％(P<0.001),65.41％(P<0.001),但对体外培养的A549肺腺癌细胞株的生长无明显影响;能够增加小鼠网状内皮系统的吞噬功能,增加溶血素水平,增强迟发超敏反应,促进小鼠巨噬细胞与脾细胞分泌IL-1,IL-2。结论:SPA可通过调节免疫来抑制肺癌增殖。更多还原

【Abstract】 Objective: To explore the inhibitory effect of algae sulfated polysaccharide(SPA) on the proliferation oflung cancer and its possible mechanism. Methods: Using in vitro cell culture and animal model to observe the effects ofSPA given by oral administration on tumor proliferation, immune function and the ability of IL-1, IL-2 secretion. Results:SPA at dose of 20, 40, 80 mg/kg significantly inhibits tumor growth with inhibitory rates of 35. 27% (P<0. 01),48. 29% (P<0. 001), 65. 41% respectively. Significant increase in phagocytic function, increase in serun hemolycinlevel. delayed allergic reaction and secrection of IL-1, IL-2 were observed after SPA administration. No direct inhibitoryeffect on proliferation of A459 adenocarcinoma cell was observed in vitro. Conclusion: SPA inhibits the growth of Lewislung cancer possibly by modulating immune function.更多还原