【摘要】 目的　探讨 p2 1、IGF II在肝硬化、肝细胞癌 (HCC)中表达的意义及其与肝细胞不典型增生(LCD)的关系。方法　用免疫组化S P法检测单纯肝硬化、癌旁肝硬化及肝细胞癌 (HCC) p2 1、IGF II表达情况。结果　p2 1、IGF II在癌旁肝硬化和单纯肝硬化组织中的阳性表达率 (92 .86 %和 75 % ;6 8%和 74 % )与HCC(5 4 .5 5 %和 36 .36 % )相比差别有显著性意义 (P <0 .0 5 )。IGF II与p2 1阳性表达存在相关关系。HBsAg阳性或伴LCD改变的肝硬化 ,p2 1、IGF II阳性率均高于HBsAg阴性或不伴有LCD改变的肝硬化 (P <0 .0 5 )。结论　 (1)在肝细胞癌变演化过程中 p2 1、IGF II可能发挥协同作用。 (2 )LCD可能是一群具有肿瘤增殖潜能的癌前细胞群 ,尤其有 p2 1、IGF II共同过度表达者 ,有发生HCC的高度危险。更多还原

【Abstract】 Objective To probe the role of ras oncogene p21 product and IGF-II in the development of cirrhotic nodules and hepatocellular carcinoma(HCC).Methods S-P immunohistochemical technique was used to analyze the expression of p21 and IGF-II was studied in 50 cases of liver cirrhosis without HCC, 28 cases of precancerous liver cirrhotic tissues, and 22 HCC cases. Results The positive rates for p21 and IGF-II in cirrhosis with or without HCC were significantly higher than these for HCC (P< 0.05). The positive rates for p21 and IGF-II in cirrhotic nodules with LCD were significantly higher than those without LCD (P< 0.05). The incidence of p21 expression in hepatocytes was significantly higher in IGF-II positive cases than that in negative ones (P< 0.01). Conclusion (1)the overexpression of p21 and IGF-II may play a synergetic role in the early stage of the development of HCC. (2)LCD are precancerous cells which have the ability to initiate neoplastic growth and present a high risk of HCC.更多还原