【摘要】 目的　检测 2 8例结直肠癌病人血清E 钙粘附素 (E Cad)浓度 ,探讨与结直肠癌侵袭性的关联性。方法　应用酶联免疫吸附法测定可溶性E Cad浓度。结果　血清E Cad浓度结直肠癌组显著高于对照组 ,DukesC组或有淋巴结转移组明显高于DukesA、B组或无淋巴结转移组 ,切除瘤体后上述各组的血清E Cad浓度均明显下降。结论　血清E Cad可能与人结直肠癌的浸润深度和淋巴结转移密切相关更多还原

【Abstract】 Objective By analyzing serum E cadherin (E Cad) concentration in 28 cases of colorectal carcinoma,we are to detect the activity of E Cad on the aggressiveness and metastasis of human colorectal cancer.Methods The serum soluble E Cad concentration was determined by ELISA method.Results The serum soluble E Cad concentration was significantly higher in patients with colorectal cancers than in healthy subjects ( P < 0.01 ). And the concentration in Dukes C group or the group with metastatic lymph nodes was much higher than in Dukes A/B group or the group without metastatic lymph nodes ( P < 0.05 ),respectively.After operation the E Cad level was dramatically decreased ( P < 0.01 ～ 0.05 ) in all cancers.Conclusion Serum E Cad level may be a key factor associated with the invasive and metastatic potential of colorectal carcinomas.更多还原