【摘要】 目的　探讨放射治疗诱发恶性肿瘤的发生率、潜伏期、治疗及预后。方法　回顾性分析 18例鼻咽癌放射治疗后诱发的恶性肿瘤 ,男 12例 ,女 6例。原发肿瘤均为低分化鳞癌 ,治疗的放射源为6 0 Co或8MV X射线 ,常规分割照射 ,照射剂量为 70～ 86Gy。 结果　 18例在放射治疗后 3～ 19年在原照射部位出现了恶性肿瘤 ,其中牙龈鳞癌 5例 ,外耳道鳞癌 3例 ,硬腭鳞癌 2例 ,舌鳞癌 2例 ,皮肤癌 2例 ,鼻咽部肉瘤 2例 ,鼻咽恶性纤维组织细胞瘤 1例 ,上颌窦骨肉瘤 1例。结论　放射治疗诱发恶性肿瘤与照射剂量有关 ,其潜伏期较长 ,适当的治疗方法可提高患者的生存率和改善患者的生存质量。更多还原

【Abstract】 Objective To study the incidence, latency, treatment and Prognosis of radiation induced malignant tumors.Methods A retrospective study was done on 18 cases of radiation induced malignancies. All original cancers were nasopharyngeal carcinoma, 12males and 6 femaes. The initial radiotherpy was 60 Co or 8MVX ray, Conventionally fractionated at dose of 70 86GY. Results After 3～19 years of the initial radiotherapy, 18 Patients developed tumors within the portal. There were: 5 squamous carcinoma of gum, 3 Squamous cell carcinoma of external auditory canal, 2 squamous cell carcinoma of hard palate, 2 squamous cell carcinoma of tongue, 2 skin carcinoma,2 nasopharyngeal sarcoma,1 malignant histiocytsis of nasopharyngeal I osteosarcoma of the maxillary bone.Conclusion Radiation induced malignant tumors have a long period of latency, Suitable treatment method could improve prognosis and quality of the patient’s life.更多还原