【摘要】 建立了人体血浆多相模型,研究了人体血浆体系中Tb(Ⅲ)物种的分布。结果表明,Tb(Ⅲ)的物种形式随着Tb(Ⅲ)的量浓度的变化而变化。当Tb(Ⅲ)的量浓度低于 4.0 0 0× 1 0 - 8mol/L时,大部分Tb(Ⅲ)物种以可溶态存在;当Tb(Ⅲ)的量浓度高于 4.0 0 0× 1 0 - 8mol/L而低于 1.667× 1 0 - 2 mol/L时,沉淀物种(TbPO4和Tb2 (CO3)3)成为Tb(Ⅲ)的主要物种。可溶的Tb(Ⅲ)在量浓度低于 1.0× 1 0 - 4 mol/L时,主要与运铁蛋白键合,分布于[Tb(Tf)]中;当Tb(Ⅲ)的量浓度高于 1.0× 1 0 - 4 mol/L时,运铁蛋白耗尽,可溶的Tb(Ⅲ)主要分布于[Tb(HSA)],[Tb2 (Tf)],[Tb(Ox)]和 [Tb(Cit)]等物种中更多还原

【Abstract】 A multi phase model of human blood plasma was developed and the Tb(Ⅲ) speciation in this system was studied. The results show that the speciation of Tb(Ⅲ) depends on the concentration of Tb(Ⅲ). When the concentration of Tb(Ⅲ) is below 4.000×10 -8 mol/L, most of Tb(Ⅲ) exists as soluble species while the concentration of Tb(Ⅲ) is in between 4.000 ×10 -8 mol/L and 1.667×10 -2 mol/L, precipitates(TbPO 4 and Tb 2 (CO 3 ) 3 ) are the dominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb(Ⅲ) is mostly bound to the transferrin to form \ when the concentration of soluble Tb(Ⅲ) is below 1.0×10 -4 mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0×10 -4 mol/L, thus available transferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in \, \[Tb 2 (Tf)\], \ and \ etc.更多还原